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Availability of data and materials The data that support the findings are available from the Exercise and Biochemical Nutritional Laboratory (EBNL) in the Department of Human Performance of Baylor University and the grant sponsor, being the Function Research Group of Kyowa Hakko Bio Co., Ltd

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This mechanistic uncertainty limits interpretation of human efficacy data

It creates a high risk of contamination that can lead to skewed data or failed experiments

Further, prophylactic use prior to TBI decreased the risk of unconsciousness or death [15]

Patients who ingest excessive paracetamol for a therapeutic purpose (e.g