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Inform patients of the signs and symptoms of acute kidney injury and instruct them to promptly report any of these signs or symptoms or persistent (or extended) nausea, vomiting, and diarrhea to their healthcare provider [see Warnings and Precautions (5.5)]

This might lead to deficiency, more so with long-term use or high doses

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Store at controlled room temperature between 15 and 30C (59 - 86F)

Tirzepatide exposure increases in a dose-proportional manner