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In this study, we highlight the contribution of ser/gly pathway alterations and hyperactivation in promoting an immunosuppressive and aggressive tumor phenotype, causing poor therapeutic responses and outcomes in GBM, which could be improved using combined sertraline/chloroquine treatment

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Sulfonamides Co-trimoxazole is a sulfonamide antibiotic commonly used in immunocompromised individuals, who are already more at risk of ADRs