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In addition to His467, another residue from the second subunit is found in the active site: Glu472 is shown to be essential by mutagenesis, and in structures is seen to orientate the catalytic Histidine

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This disruption promotes fatty liver disease and hepatocellular carcinoma through interference with critical processes such as autophagy ( Table 3 )

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Depression is ultimately a disease in which neurons and synaptic contacts are lost in the hippocampus

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Toxicity and detoxification of heavy metals during plant growth and metabolism

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