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Commonly encountered agents were summarized by proposed mechanism, evidence tier, and perioperative considerations ( Table 1 )

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This restriction is due to the rigid nature of the amide (peptide) bond

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The integration of MNs with deformable liposomes (e.g., ethosomes, transfersomes) enhances delivery efficacy, since the pliable vesicles can navigate via microchannels and release their contents directly into the dermis [275]