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Gradual Dose Escalation Gradual dose escalation proceeds with: Weeks 1-4: 1 mg once daily Weeks 5-8: 2 mg once daily Thereafter: Adjustment based on individual response and goals Dosing Frequency Options Dosing frequency most commonly involves once daily administration (morning or evening), with alternative protocols using 2-3 times per week at 2 mg per injection

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The UPR signaling pathway is mainly mediated by protein kinase RNA-like ER kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)