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Mitochondrial impairments have been linked to reduced ATP synthesis, synaptic loss, and tau accumulation, while aberrant HDAC activity influences gene expression related to neuroplasticity and neuroprotection and correlates with cognitive decline across aging and neurodegenerative disorders

PMID: 20552409

doi:10.1038/ajg.2009.45 6 Palmery, M., Saraceno, A., Vaiarelli, A., Carlomagno, G

(PubMed) Holick MF, Matsuoka LY, Wortsman J

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