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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

In the knockout mice, there was no significant decrease in body weight or lipolysis, thus indicating the importance of the beta-adrenergic pathways in weight loss

Besides parameters related to the transition from wakefulness to sleep, no other EEG qualities were evaluated for the purpose of this study

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Pharmacol Res - Mod Chin Med [Internet]