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In a human study published that same year, Khavinson and colleagues observed that elderly human subjects who received epithalamin treatment for two to three years experienced a 1.6-1.8 fold decreased mortality rate compared with a control group

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In contrast, properly protected formulations retained over 92% activity for six months

However, contradictory findings were obtained in a recent study which concluded that mutant TDP-43 A315T does not impair mitochondrial bioenergetics in vitro and in vivo (Kawamata et al., 2017)