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318,319 In a 3D in vitro microtissue model, administration of Selonsertib decreased the measurements of specific disease parameters, such as the secretion of the profibrotic factor (procollagen type I), proinflammatory cytokines (TNF- and IL-6), and chemokines (MCP-1, MIP-1, IL-8, IP-10), in accordance with clinical observations

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