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When a generalized and severe stage of inflammation is achieved, patients may develop sepsis, a life-threatening condition [124]

Early work in Paul Talalays lab at Johns Hopkins identified NQO1 as a key and highly responsive Phase 2 enzyme, the measurement of which has been a reliable and highly predictive indicator of the cytoprotective potential of both natural and synthetic compounds [78]

doi: 10.1590/S0103-84782010000300032 161 PierothRPaverSDaySLammersfeldC

[DOI] [PubMed] [Google Scholar] 32.McNeill E., Crabtree M.J., Sahgal N., Patel J., Chuaiphichai S., Iqbal A.J., Hale A.B., Greaves D.R., Channon K.M

These enzymes achieve this by catalyzing the nucleophilic attack of the thiol group of glutathione on electrophilic centers of various substrates

The anti-catabolic effects prove most valuable during dieting phases