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In some embodiments, the otoprotectant is a compound comprising a urea-thiophene-carboxamide moiety of Formula (IV): wherein X is a heteroatom that includes N, 0, or S

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[12] Healthcare providers will monitor any unusual responses and can adjust treatment if any potential interaction is suspected

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Because all 12 patients scored a 5 on the Global Response Assessment, this therapy was considered successful

BPC-157 is most appropriate if gut health is a contributing factor