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demonstrated that oleuropein ameliorates collagen-induced arthritis (CIA) in a mouse model by activating the Nrf2/HO-1 antioxidant pathway and inhibiting the activation of the NF-B and MAPK pathways [117]

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Even though it is possible that CD38 might directly affect the brain, targeting CD38 abrogated disease-associated T H 17 cell immunity, potentially by breaking meningeal to cortical communication via modulation of IL-17A/IL-1 crosstalk (Fig

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