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In children the dose is 15mg/kg up to 60mg/kg/day

When combined with levocarnitine, the theoretical benefit is an additive or even synergistic effect on hepatic fat reduction: tirzepatide reduces the caloric load and improves systemic insulin sensitivity, while levocarnitine enhances the liver ability to oxidize existing fat stores and reduce inflammation

Matrix Metalloproteinases (MMPs) and Their Inhibitors (TIMPs): The balance between MMPs (which break down the ECM) and TIMPs (which inhibit MMPs) is critical for tissue homeostasis