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The gene encoding a subunit of the cystine transporter SLC7A11 (xCT) is another Nrf2 target (Sasaki et al., 2002), whose product increases the availability of cysteine for glutathione synthesis

The MTHFR enzyme is responsible for converting tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), and reduced enzyme activity may influence methylation efficiency, particularly if riboflavin (vitamin B2) status is suboptimal

The serum lipid peroxidation was higher, while the serum GPX4 concentration was lower in GDM women (Mauri et al., 2021)

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