Ferroptosis, an iron-dependent form of regulated cell death, is characterized by the accumulation of lipid peroxides and is primarily regulated by the glutathione peroxidase 4 (GPX4) enzyme [14,15,16,17]
This means that a greater amount of the active substance reaches the systemic circulation, potentially increasing its effectiveness
This approach is often more sophisticated than relying on a single intervention
In vitro human plasma stability Human plasma was preheated at 37 C for 15 min before being spiked with a final concentration of 0.25 mM of the peptide or conjugate
ACS Nano 10 , 25912599, (2016)
One of the peptides described to act in this way is H-Val- Gly-Val-Ala-Pro-Gly-OH (VGVAPG) (Product: 4010536 Chemotactic Domain of Elastin)