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The components of this inflammatory milieu are responsible of evoking allodynic and hyperalgesic responses in part because of a persistent sensitization of the nociceptive neurons and partially by the initiation of a facilitated state of processing of the afferent input in the spinal cord

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Soluble autoimmunity markers B lymphocyte activating factor (BAFF) has been identified in many autoimmune diseases (519) as it regulates survival and maturation of B cells to control the IL-10 production of regulatory B cells (520, 521)

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