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Mass spectrometry ESIMS experiments were performed on a quadrupole time-of-flight (qTOF) Bruker Maxis Impact mass spectrometer (Bruker Daltonik GmbH) calibrated with a commercial ESI-TOF tuning mix (Sigma-Aldrich)

discovered that administering roburic acid (RBA), a component of the anti-RA herb Gentiana, to RA joints can effectively block the ERK/HIF-1/GLUT1 pathway, fostering the transition from M1 to M2 macrophage phenotype, suppressing inflammatory cytokines, and enhancing tissue repair, thereby yielding potent therapeutic outcomes for RA (142)