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doi: 10.1016/j.regpep.2012.12.007

A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published

We know that chronic inflammatory diseases (including PD) are very long lasting, therefore, an adequate period of treatment is required to stop the course of the disease and for progressive reabsorption of the plaque