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Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa

& Liu, J

doi: 10.1093/ajcn/51.2.290

These include chemical modifications (e.g., oxidation, sulfonation), physical treatments (e.g., ultrasonication, thermal processing), biological methods (e.g., enzymatic or microbial incorporation), and functionalization strategies (e.g., grafting with amines, peptides, or silanes), as illustrated in Figure 5

STSA 2014, 2014