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The act of administering an unapproved drug to a human, including self-administration, is prohibited under the Federal Food, Drug, and Cosmetic Act

Harma M, Erel O

8 Conclusion In conclusion, the consideration of the effects of tamoxifen on both tumor and non-tumor cells through oxidative stress involves the interaction of several mechanisms associated with the therapeutic success, acquired resistance, or toxicity of tamoxifen

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However, because of a lower ratio of kidney/liver -lyase activity in human than rodents, kidney selectivity remains to be confirmed

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