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Glutathiones role as a cofactor in mercapturic acid pathway detoxification and its direct interaction with reactive oxygen species (ROS) and reactive nitrogen species (RNS) make it a central compound in oxidative stress biology research

10.12998/wjcc.v10.i22.7653 76 OlivaS.Di NardoG.FerrariF.MallardoS.RossiP.PatriziG.et al (2012)

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Long-term studies are critical to ensure that hydrogel degradation products do not induce chronic toxicity, immunogenic reactions, or interference with organ function, especially in organs at risk such as the bladder, rectum, and bowel