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Life Sci 284:119911 Sayed AM, Abdel-Fattah MM, Arab HH, Mohamed WR, Hassanein EH (2022) Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: role of TLR4/NF-B and c-Fos/c-Jun pro-inflammatory pathways and PPAR-/SIRT1 cytoprotective signals

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Firstly, SeNPs exhibit enhanced bioavailability, allowing for more efficient uptake and targeted delivery of Se to tissues like the thyroid, while reducing nonspecific accumulation that could lead to toxicity [29]