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Following multiple doses, mean insulin-like growth factor (IGF-1) levels remained above baseline for up to 28 days

Downregulating MYCN in IMR-5/75 decreased caspase activation for both treatments, while inducing MYCN expression in SH-SY5Y/MYCN increased caspase activation, although the differences were not statistically significant ( Figure 4D )

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[3] The speed of response depends on multiple factors including the severity and duration of deficiency, the presence of neurological complications, and individual metabolic differences