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This cascade results in the cleavage of Gasdermin D, leading to the formation of membrane pores that may contribute to cell lysis and the release of the proinflammatory cytokines interleukin (IL)-1 and IL-18

As the disease progresses, additional brain regions involved in higher cognitive functions are affected, leading to more widespread cognitive and behavioral impairments ( 4 Biochemical and molecular mechanisms in PD Parkinsons disease is a chronic neurodegenerative disorder that is also progressive, similar to AD, and mainly affects the motor system, though non-motor symptoms are also prevalent

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doi: 10.1021/acschemneuro.2c00580 116 YanH.QinQ.YanS.ChenJ.YangY.LiT.et al

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