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2) The results of the study performed by Khvatova et al demonstrate that DSIP significantly enhances the efficiency of oxidative phosphorylation in rat brain mitochondria and brain homogenates, and provides complete protection against hypoxia-induced reductions in mitochondrial respiratory activity

But this theory needs more long-term data to confirm

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This increased permeability allows lipopolysaccharides (LPS), food antigens, and microbial byproducts (PAMPs) to translocate into circulation, triggering systemic immune activation and placing further burden on mast cells 18

doi:10.1111/j.1398-9995.2009.02325.x Gray SL, Anderson ML, Dublin S, et al