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The main function of granulosa cells, relevant to oocyte development and ovarian functions, is steroidogenesis, for which different signaling pathways, including Jak/STAT, PI3K/Akt, and pro-MAPK/ERK1/2, regulate this fundamental process, all of which have a shared modulator named IGF

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To address this question, we analyzed the capacity to restore the redox balance after reductive challenge in GSH-depleted cells producing periplasmic roGFP2 as described before