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NAD + depletion, as previously described, causes mitochondrial dysfunction, a decline in energy production and accumulated ROS that produce high oxidative stress

Histopathological studies reveal that CQ group and CQ combined with L-ARG group showed vigorous morphological changes i.e., deformed epidermis and cells, increased epidermal thickness, vacuolization and loss of membrane integrity

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In the CD spectrum, a shoulder peak appeared at ~220 nm after illuminating 1 NF , indicating a -sheet-rich secondary structure of the formed 2 NP (ref