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Novel small molecule inhibitors of nicotinamide N-methyltransferase (NNMT)

The liberation of FA from TAG by adipocyte lipolysis is also important to supply substrate for hepatic synthesis of very-low-density lipoproteins (VLDLs)

Regular supplementation helps prevent neurological symptoms linked to deficiency

Other potential side effects include headaches and digestive discomfort

Additional information Peer review information Nature Metabolism thanks Dominique Langin and the other, anonymous reviewers for their contribution to the peer review of this work