cGAS/STING pathway in microglial diseases In the context of neurodegeneration, amplification of microglial cGAS-STING signaling, along with IFN production and cGAS-driven senescence, has been implicated as a disease-promoting mechanism in female mice (Carling et al., 2024)
However, its use in humans remains challenging because to allergic responses, discomfort at administration sites, and other serious toxic events including hemolysis, nonspecific cytotoxic effects, itching feeling, and hypersensitivity during therapeutic therapy
The Morris water maze, a hippocampal-dependent spatial learning task requiring rats to locate a pedestal hidden beneath the surface of the water by orienting themselves to extra- maze cues was employed to evaluate the impact of the HGF antagonist, Hinge, on the pro- cognitive effects of Dihexa
This trend is also seen in Figure 2G , which presents a scatter plot of the study group subtraction from control group
10.1038/srep18065 11 BelinS.ZuloagaK
doi:10.1111/ced.12069 Schindl A, Neumann R
