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In summary, the discovery of ferroptosis expands our understanding of CD in CCVDs, and targeting ferroptosis will provide a new strategy and broaden thoughts for the prevention and treatment of CCVDs

Immunohistochemical analysis displayed that metformin did not reduce MMP13 expression and only partially decreased ADAMTS5 levels, and Collagen II in Nrf2 KO mice were not significantly influenced by metformin treatment (Fig