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Then, by changing the surface properties of the MAPHP-particle system through coating surfactants (e.g., T80), by overcoating with ApoE, B, A-I or by complexing with iron, the system could mimic the behavior of the apolipoprotein E- (ApoE) and apolipoprotein A-I (ApoA-I)-NPs, respectively, so as to cross the BBB and take the excess metals out of the brain with very limited toxicity (Davson and Segal, 1995

No, from a chemical standpoint, mixing these water-soluble peptides right before use does not cause them to degrade or neutralize each other

In summary, the regulatory role of mitophagy is not simply "beneficial" or "detrimental", but a bidirectional regulatory process co-regulated by multiple factors