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Chronic alcohol exposure induces the cytochrome P450 2E1 isozyme system that also metabolizes acetaminophen to acetaldehyde, allowing for acetaminophen hepatotoxicity to occur at lower doses

Khavinson VKh, Bondarev IE, Butyugov AA

Weight loss curves at the highest doses had not fully plateaued at the study endpoints, suggesting even greater losses with extended treatment

Metabolic:Negative nitrogen balance due to protein catabolism

As of June 2026, AOD-9604 is listed as Nominated but Withdrawn , meaning it is no longer actively under Category 2 nomination

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