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Mouse tumor implantation assay Four-week-old female athymic nude mice (SLAC Laboratory) were housed and maintained under specific pathogen-free (SPF) conditions according to institutional guidelines

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By contrast, tesamorelin's N-terminal trans-2-hexenoic acid modification addresses a different problem: GHRH has a short half-life in vivo due to dipeptidyl peptidase IV cleavage at the Tyr1-Ala2 bond