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Studies show FOXO4-DRI treatment reduces senescent cell markers including p16, p21, and senescence-associated -galactosidase activity by over 50% in expanded human chondrocytes at population doubling level 9 (PDL9), the stage typically used for clinical implantation

No controlled human-lifespan trial was identified

The rationale for combining these three peptides extends beyond simple additive effects to encompass true biological synergy, where coordinated activation of complementary pathways produces outcomes unattainable by individual components alone

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