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To rigorously investigate the function of the Cpt1a gene in tumorigenesis, we developed a transgenic mouse model with spontaneous pulmonary carcinoma and targeted knockout of Cpt1a specifically in pulmonary epithelial cells ( Sftpc- CreER T2

However, higher levels of intracellular GSH present a challenge for developing G-site-specific inhibitors [115,116]

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The DCCT study demonstrated that intensive insulin therapy in T1D significantly reduced the risk of DPN by 64% and cardiovascular autonomic neuropathy by 45% compared with conventional treatment, with these benefits persisting for over 13 years after the trial ended [60]

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Key Clinical Statistics on Medication-Induced Diarrhea Up to 25% of patients develop antibiotic-associated diarrhea after taking broad-spectrum penicillin drugs (American Journal of Gastroenterology, 2021)