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Most healthcare providers start with a standard dose and adjust based on your response

When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

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The fatigue tied to B12 deficiency is often a deep, ongoing exhaustion that rest does not fully relieve

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