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aemia, certain gut surgeries, or dietary restrictions

Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

One group of mice that were switched from WD to LD received these same sterile saline injections for the remainder of the study (termed the WD/LD-V group

Furthermore, it has been identified as an early metabolic change and a prominent feature of the disease (Swerdlow, 2018)