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Methylcobalamin should not be used in patients with early hereditary optic nerve atrophy (Lebers disease)

PMC 4575440

Always allow vials to come to room temperature before opening to reduce condensation, and avoid repeated freeze-thaw cycles

Therefore, for anyone considering such a combination, the following apply: Extreme Caution and Medical Supervision: This is not a self-experimentation endeavor

Avoid repeated freeze-thaw cycles and keep materials in their original sealed container until ready for use

Handling and Storage Recommendations To preserve the quality of the product and support safe laboratory practices, follow these guidelines: Store at 20 C or below