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This was further supported by gene set analysis which indicated IR most potently regulated of metabolic pathways (glucose, pyruvate and cholesterol metabolism), as well as genes in the hypoxia inducible factor and protein turnover pathways, and genes implicated in diabetes (Supplementary Table 2)

Rao et al, demonstrated that acidic conditions, rather than lactate itself, play a pivotal role in promoting the differentiation of FOXP3 + Tregs from conventional CD4 + T cells

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Additionally, reduced levels of N-arachidonoyl phenylalanine and N-arachidonoyl tryptophan were detected in the MMA group

Kuang, R., OKeefe, S