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Taboada M, Cariena A, Moreno E, Rodrguez N, Domnguez MJ, Casal A, et al
634 AAK1 inhibitor LX-9211: Junctional protein 2-associated kinase 1 (AAK1) is widely expressed in the brain and spinal cord and is a viable target for the treatment of neuropathic pain, and BMS-986176/LX-9211 is a novel class of bis(iso)aryl ethers that are highly selective, CNS-permeable, and potent AAK1 inhibitors
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doi: 10.1016/j.lfs.2021.120274 27 EltayebKAlfieriRFumarolaCBonelliMGalettiMCavazzoniAet al
To enhance the pharmacological properties of the ruthenium catalyst, provide cancer selectivity for the treatment, and enable the treatment of challenging hypoxic tumors, the metal complexes were covalently conjugated to the side chains of polymers with a carbon fluorinated moiety that could co-deliver oxygen to the tumor
