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[DOI] [PMC free article] [PubMed] [Google Scholar] [50].Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, et al

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Accessed September 13, 2019

Through high-frequency ctDNA detection, clinicians can detect resistance trends (such as RRM2 copy number doubling) earlier than imaging, and guide the adjustment of treatment plans (such as switching to RRM2 inhibitor 3-AP or combined with METTL3 inhibitor) to avoid ineffective chemotherapy

This timeline allows for the natural cycle of skin cell turnover, which usually takes about 28 to 30 days

2021a) (Fig