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Third, clinical efforts should include multicenter AD biobanks to validate associations between biomarkers such as ACSL4 and GPX4 and cognitive scores, as well as combined clinical trials of ferroptosis inhibitors with anti-A monoclonal antibodies to examine therapeutic benefit in antibody-resistant patients

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To overcome these obstacles, researchers have developed various delivery systems, including lipids, peptides, and polymers, for mRNA delivery both in vitro and in vivo