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Oxidative Stress in Alzheimers Disease The brain requires an abundant supply of both oxygen and glucose since the oxidation of glucose under aerobic conditions is the primary energy source for the brain

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Thus, the negative regulation of gliotoxin biosynthesis via GtmA must be counter-balanced by GliT activity to avoid Methyl/Met cycle dysregulation, SAM depletion and trans consequences on global cellular biochemistry in A