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Levels decrease with age
Moreover in BALB/c mice, inclusion of GSH in the drinking water decreased viral titer in both lung and trachea homogenates after intranasal inoculation with a mouse-adapted influenza strain A/X-31 ( Our group demonstrated that GSH was able to inhibit also HIV expression in human macrophages at late stages and this was related to the selective decrease of specific glycoproteins, such as gp120, which are notably rich in disulfide bonds ( Next to this, it has been also reported that in vitro infection and replication of human herpes simplex virus type 1 (HSV-1) induced a dramatic decrease in intracellular GSH
One study found that Rb inhibits the expression of SLC1A5 and the activity of GLS1 by regulating E2F-3, consequently blocking the intake and metabolic processing of Gln
Reddy, S., Ramsubeik, K., Vega, K
