Some effects, such as improvements in nerve function, may take longer
Cyanocobalamin works fine in many clinical contexts (and is the standard for injections), but as a daily supplement for long-term optimization, methylcobalamin is more direct and more commonly preferred by performance-oriented clinicians
On the other hand, a severe B12 deficiency can also lead to weight loss
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Joint pain (chronic knee, shoulder, hip): Anti-inflammatory effects can begin at 2 to 3 weeks