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1 Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons, leading to muscle weakness, paralysis, and ultimately respiratory failure (13)

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J Biol Chem 285:3087530883 Huster D, Purnat TD, Burkhead JL, Ralle M, Fiehn O, Stuckert F et al (2007) High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease

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New York: Ballantine Books

For other LRP volumes keep to a ratio of LRP to density barrier of 2:1