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doi: 10.3390/pharmaceutics12121186 31 IshiguroTOhataHSatoAYamawakiKEnomotoTOkamotoK

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Its actions, however, are highly context-dependent, and under conditions of NAD + depletion, specific cell types, dosing imbalances, or advanced disease, SIRT1 may exacerbate oxidative damage by impairing repair enzyme activity, exacerbating mitochondrial dysfunction, and weakening antioxidant responses

When your B12 levels are optimal, your body can efficiently convert food into glucose your main source of fuel