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The estimated mean change in body weight at week 68 was 20.4% with CagriSema versus 3.0% with placebo (a difference of about 17 percentage points), and more CagriSema participants reached weight-loss thresholds of 5%, 20%, 25%, and 30% than placebo
This wide therapeutic window provides reassurance about acute safety
Oxidative DNA stress occurring after cerebral ischemia is associated with a decrease in apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) expression (Fujimura et al., 1999)