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Deacetylation As the principal mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin3 regulates protein activity and stability through substrate-specific lysine deacetylation (Kac), thereby participating in pathophysiological processes such as cellular oxidative stress, autophagy, and cell death [36]

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P., Marachelian, A., Groshen, S., Tsao-Wei, D., Matthay, K

In a diabetic retinopathy model, AST treatment elevated the levels of the antioxidant enzyme heme oxygenase-1 (HO-1) and preserved homeostasis for retinal ganglion cells (Yoshihisa et al., 2014)

Allison, K